
They named it for king Louis IX of France, and it quickly became the regional center of the French Illinois Country. Maxent, Pierre Laclède and Auguste Chouteau, all from New Orleans.

Louis was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. From roughly 900 to 1500 CE, it was a regional center of Mississippian culture, based in Cahokia east of the river, and extending across the continent along the Mississippi and its tributaries. It is the largest metropolitan area in Missouri and the second largest in Illinois.īefore European settlement, the area had been occupied for thousands of years by various Native American cultures. In 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is located near the confluence of the Mississippi and the Missouri rivers. Louis ( / s eɪ n t ˈ l uː ɪ s, s ən t ˈ l uː ɪ s/) is the second-largest city in Missouri, United States.
